|
|
| Nomenclature |
|
Symbol:
|
Artm1.1Jdz
|
|
Name:
|
androgen receptor;
targeted mutation 1.1, Jeffrey D Zajac
|
|
MGI ID: |
MGI:3716756 |
|
Synonyms: |
ARdeltaZF2 |
|
Gene:
|
Ar
Location:
ChrX:98149721-98323215 bp, + strand
Genetic Position: ChrX,
42.82 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:123057
|
|
Parent Cell Line:
| Not Specified (ES Cell) |
|
Strain of Origin:
|
129X1/SvJ
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutation: | |
Intragenic deletion |
| |
|
Mutation details: Cre-mediated recombination in the germline resulted in the loss of exon 3, which encodes the second zinc finger of the DNA-binding domain. This deletion has been designed to retain the normal reading frame so that the mutant AR can bind ligand but is unable to bind DNA and regulate target gene transcription. (J:123057)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
| References |
|
Original: |
J:123057
Notini AJ et al.,
"Genomic actions of the androgen receptor are required for normal male sexual differentiation in a mouse model."
J Mol Endocrinol 2005 Dec;35(3):547-55
|
|
All: |
5 reference(s)
|
|
Analysis Tools
