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| Nomenclature |
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Symbol:
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Pink1tm1Shn
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Name:
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PTEN induced putative kinase 1;
targeted mutation 1, Jie Shen
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MGI ID: |
MGI:3716083 |
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Synonyms: |
Pink1- |
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Gene:
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Pink1
Location:
Chr4:138313409-138326307 bp, - strand
Genetic Position: Chr4,
70.14 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:122728
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 4-7 were replaced with a pgk-neo cassette via cre mediated recombination, thereby removing the majority of the kinase domain and creating a nonsense mutation at the beginning of exon 8. Northern blot confirmed absence of transcript in mutants. (J:122728)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Pink1 Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:122728
Kitada T et al.,
"From the Cover: Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice."
Proc Natl Acad Sci U S A 2007 Jul 3;104(27):11441-6
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All: |
7 reference(s)
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Analysis Tools
