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| Nomenclature |
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Symbol:
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Thbdtm2Emc
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Name:
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thrombomodulin;
targeted mutation 2, Edward M Conway
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MGI ID: |
MGI:3712468 |
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Synonyms: |
TMLeDneo |
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Gene:
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Thbd
Location:
Chr2:148404466-148408188 bp, - strand
Genetic Position: Chr2,
73.45 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:118000
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The wild-type coding region was replaced with one lacking sequences encoding the N-terminal thrombomodulin domain and containing a neo cassette inserted downstream of the cytoplasmic tail. (J:118000)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Thbd Mutation:
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1 strain or line available |
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| References |
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Original: |
J:118000
Conway EM et al.,
"The lectin-like domain of thrombomodulin confers protection from neutrophil-mediated tissue damage by suppressing adhesion molecule expression via nuclear factor kappaB and mitogen-activated protein kinase pathways."
J Exp Med 2002 Sep 2;196(5):565-77
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All: |
1 reference(s)
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Analysis Tools
