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| Nomenclature |
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Symbol:
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Duox2thyd
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Name:
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dual oxidase 2;
thyroid dyshormonogenesis
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MGI ID: |
MGI:3712359 |
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Gene:
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Duox2
Location:
Chr2:122279247-122298165 bp, - strand
Genetic Position: Chr2,
60.61 cM
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Mutation
origin |
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Strain of Origin:
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B6.129-Tnfrsf1atm1Mak/J
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Mutation
description |
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Allele
Type: | |
Spontaneous |
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Mutation: | |
Single point mutation |
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Mutation details: A spontaneous C to T transition in exon 16 causes a change from a highly conserved valine to glycine at amino acid position 674. (J:121821)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:121821
Johnson KR et al.,
"Congenital hypothyroidism dwarfism and hearing impairment caused by a missense mutation in the mouse dual oxidase 2 gene, Duox2"
Mol Endocrinol 2007 Jul;21(7):1593-602
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All: |
1 reference(s)
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Analysis Tools
