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| Nomenclature |
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Symbol:
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Tg(Cyp19a1-cre)5912Gle
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Name:
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transgene insertion 5912, Gustavo Leone
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MGI ID: |
MGI:3712298 |
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Synonyms: |
CYP19-Cre |
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Transgene:
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Tg(Cyp19a1-cre)5912Gle
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (Cre/Flp) |
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Mutation: | |
Insertion |
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Mutation details: This transgene uses the cytochrome P450, family 19, subfamily a, polypeptide 1 promoter to drive expression of cre recombinase in the placenta. The transgene also contains an IRES-luciferase, the rabbit beta-globin intron and the SV-40 polyA signal. When crossed to R26R reporter mice, the 5912 founder line exhibited cre activity throughout the spongiotrophoblast and labyrinth trophoblast of E13.5 placentas (only a small percentage of fetuses display X-gal in the internal organs.) The transgene is active by E6.5 in early diploid trophoblast cells having initiated commitment to a differentiated state but is inactive in early, undifferentiated trophoblast stem cells. Strength of cre expression was related to parental inheritance, with maternal inheritance providing the strongest, most consistent placental expression. This line was studied in detail. (J:121714)
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Recombinase activity
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:121714
Wenzel PL et al.,
"Expression of Cre recombinase in early diploid trophoblast cells of the mouse placenta."
Genesis 2007 Mar;45(3):129-34
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All: |
2 reference(s)
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Analysis Tools
