|
|
| Nomenclature |
|
Symbol:
|
Plod1tm1Soin
|
|
Name:
|
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1;
targeted mutation 1, Raija Soininen
|
|
MGI ID: |
MGI:3712146 |
|
Synonyms: |
Plod1- |
|
Gene:
|
Plod1
Location:
Chr4:147909753-147936767 bp, - strand
Genetic Position: Chr4,
78.57 cM
|
|
Gait abnormalities in Plod1tm1Soin/Plod1tm1Soin mice
Show the 2 image(s) involving this allele.
|
 |
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:120891
|
|
Parent Cell Line:
| W4 (ES Cell) |
|
Strain of Origin:
|
129S6/SvEvTac
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutations: | |
Insertion, Intragenic deletion |
| |
|
Mutation details: The lacZ-neo reporter was fused in-frame to exon 2. Homologous recombination led to the deletion of exons 3-6 and fusion of the endogenous 129 bp 5' sequence into the bacterial beta-gal gene. RT-PCR confirmed absence of transcript in mutant heart. (J:120891)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Plod1 Mutation:
|
3 strains or lines available |
|
| References |
|
Original: |
J:120891
Takaluoma K et al.,
"Tissue-specific changes in the hydroxylysine content and cross-links of collagens and alterations in fibril morphology in lysyl hydroxylase 1 knock-out mice."
J Biol Chem 2007 Mar 2;282(9):6588-96
|
|
All: |
1 reference(s)
|
|
Analysis Tools
