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| Nomenclature |
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Symbol:
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Tpmttm1Rlng
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Name:
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thiopurine methyltransferase;
targeted mutation 1, Mary V Relling
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MGI ID: |
MGI:3712056 |
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Synonyms: |
Tpmt- |
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Gene:
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Tpmt
Location:
Chr13:47025170-47044737 bp, - strand
Genetic Position: Chr13,
24.5 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:121737
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Sequence containing exons V and VI was replaced with a neomycin resistance gene. (J:121737)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Tpmt Mutation:
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7 strains or lines available |
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| References |
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Original: |
J:121737
Hartford C et al.,
"Differential effects of targeted disruption of thiopurine methyltransferase on mercaptopurine and thioguanine pharmacodynamics."
Cancer Res 2007 May 15;67(10):4965-72
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All: |
1 reference(s)
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Analysis Tools
