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| Nomenclature |
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Symbol:
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Aqp2tm1(cre)Blyg
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Name:
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aquaporin 2;
targeted mutation 1, Baoli Yang
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MGI ID: |
MGI:3711456 |
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Synonyms: |
Aqpdelta230 |
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Gene:
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Aqp2
Location:
Chr15:99579056-99584545 bp, + strand
Genetic Position: Chr15,
56.13 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:121445
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: A targeting vector was designed to insert an IRES-cre-ER-neo into exon 4. This insertion resulted in the loss of the protein kinase A phosphorylation site (S256), but the putative apical localization signal remained. RT-PCR demonstrates no expression for the downstream segment of exon 4, however, transcript for the upstream portion including cre recombinase, was detected. (J:121445)
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Recombinase activity
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Driver:
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Aqp2
Summary of all recombinase alleles
driven by Aqp2.
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MGI has not yet included tissue activity data for this allele in any anatomical systems.
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Aqp2 Mutation:
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6 strains or lines available |
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| References |
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Original: |
J:121445
Shi PP et al.,
"Nephrogenic diabetes insipidus in mice caused by deleting COOH-terminal tail of aquaporin-2."
Am J Physiol Renal Physiol 2007 May;292(5):F1334-44
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All: |
1 reference(s)
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Analysis Tools
