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| Nomenclature |
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Symbol:
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Dnmt3atm1Jae
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Name:
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DNA methyltransferase 3A;
targeted mutation 1, Rudolf Jaenisch
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MGI ID: |
MGI:3711072 |
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Synonyms: |
Dnmt3a2lox |
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Gene:
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Dnmt3a
Location:
Chr12:3806007-3914443 bp, + strand
Genetic Position: Chr12,
1.99 cM, cytoband A2-A3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:121563
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Parent Cell Line:
| v6.5 (ES Cell) |
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Strain of Origin:
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(C57BL/6 x 129S4/SvJae)F1
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: An frt-flanked neomycin resistance gene was inserted into intron 17 and loxP sites were inserted into introns 17 and 20. The neo was removed via translient flp recombinase expression. (J:121563)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:121563
Nguyen S et al.,
"Ablation of de novo DNA methyltransferase Dnmt3a in the nervous system leads to neuromuscular defects and shortened lifespan."
Dev Dyn 2007 Jun;236(6):1663-76
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All: |
3 reference(s)
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Analysis Tools
