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| Nomenclature |
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Symbol:
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Tg(HLA-A/H2-D/B2M)1Dvs
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Name:
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transgene insertion 1, David Serreze
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MGI ID: |
MGI:3711057 |
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Synonyms: |
HDD, HHD |
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Transgene:
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Tg(HLA-A/H2-D/B2M)1Dvs
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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NOD/ShiLtDvs
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This transgene encodes a human B2-microglubulin (B2M) covalently linked to the MHC class 1, alpha1 and alpha2 binding domains of the human HLA-A2.1 gene, and the alpha3, cytoplasmic and transmembrane domains of the murine H2-Db. The construct was injected into fertilized NOD/ShiLtDvs oocytes. The construct was originally described in J:41077 and used to create a different transgenic line. (J:41077, J:121685)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
The HDD construct was created and used to generate a differnet transgenic mouse line in J:41077.
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| References |
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Original: |
J:121685
Takaki T et al.,
"HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes."
J Immunol 2006 Mar 1;176(5):3257-65
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All: |
11 reference(s)
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Analysis Tools
