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| Nomenclature |
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Symbol:
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Slc4a4tm1Ges
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Name:
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solute carrier family 4 (anion exchanger), member 4;
targeted mutation 1, Gary E Shull
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MGI ID: |
MGI:3710188 |
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Synonyms: |
Nbc1- |
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Gene:
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Slc4a4
Location:
Chr5:88886818-89239653 bp, + strand
Genetic Position: Chr5,
44.1 cM, cytoband E2
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Follicular organization of the spleen is disrupted in Slc4a4tm1Ges/Slc4a4tm1Ges mice
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:120867
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Part of exon 9 was replaced with a neomycin resistance gene. Absence of transcript was confirmed by Northern blot of mutant kidney, small intestine and colon. (J:120867)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:120867
Gawenis LR et al.,
"Colonic anion secretory defects and metabolic acidosis in mice lacking the NBC1 Na+/HCO3- cotransporter."
J Biol Chem 2007 Mar 23;282(12):9042-52
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All: |
3 reference(s)
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Analysis Tools
