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| Nomenclature |
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Symbol:
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Bdkrb2/Bdkrb1tm1Mki
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Name:
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bradykinin receptor, beta 1;
targeted mutation 1, Masao Kakoki
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MGI ID: |
MGI:3710159 |
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Synonyms: |
B1RB2R-null, Bdkrb1-/Bdkrb2- |
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Gene:
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Bdkrb1
Location:
Chr12:105604091-105605428 bp, + strand
Genetic Position: Chr12,
55.81 cM, cytoband F1
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Histological changes in the postischemic kidneys of wild type, Bdkrb2tm1Jfh/Bdkrb2tm1Jfh and Bdkrb2/Bdkrb1tm1Mki/Bdkrb2/Bdkrb1tm1Mki mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:121339
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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C57BL/6J
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intergenic deletion |
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Mutation details: A targeting vector was designed to replace bradykinin receptor, beta 2 exon 3 and the bradykinin receptor, beta 1 exon with a floxed neomycin resistance cassette. (J:121339)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:121339
Kakoki M et al.,
"Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury."
Proc Natl Acad Sci U S A 2007 May 1;104(18):7576-81
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All: |
3 reference(s)
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Analysis Tools
