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| Nomenclature |
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Symbol:
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Gucy2ftm1Wbae
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Name:
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guanylate cyclase 2f;
targeted mutation 1, Wolfgang Baehr
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MGI ID: |
MGI:3709985 |
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Synonyms: |
GC2-, RetGC2- |
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Gene:
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Gucy2f
Location:
ChrX:142081160-142196931 bp, - strand
Genetic Position: ChrX,
62.85 cM
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Abnormal rod outer segments in Gucy2etm1Gar/Gucy2etm1Gar Gucy2ftm1Wbae/Gucy2ftm1Wbae mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:120903
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Parent Cell Line:
| iTL1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A neomycin resistance cassette replaced the ATG and peptide leader sequence encoded by exon 2. Immunoblot confirmed absence of protein in mutant retinal lysates. (J:120903)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Gucy2f Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:120903
Baehr W et al.,
"The function of guanylate cyclase 1 and guanylate cyclase 2 in rod and cone photoreceptors."
J Biol Chem 2007 Mar 23;282(12):8837-47
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All: |
4 reference(s)
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Analysis Tools
