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| Nomenclature |
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Symbol:
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Tg(CD19-BTK*K430R)XK24Rwhe
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Name:
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transgene insertion XK24, Rudolf Hendriks
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MGI ID: |
MGI:3709262 |
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Synonyms: |
Btk-K430R, CD19-hBtkK430R |
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Transgene:
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Tg(CD19-BTK*K430R)XK24Rwhe
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A composite fragment composed of 400bp from exons 1-3 of a BTK cDNA as well as 27kb genomic fragment containing exons 3-19 of BTK was placed under the control of the promoter region of human CD19. A K430R mutation was introduced into this construct by double stranded site-directed mutagenesis. (J:120989)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:120989
Middendorp S et al.,
"Function of Bruton's tyrosine kinase during B cell development is partially independent of its catalytic activity."
J Immunol 2003 Dec 1;171(11):5988-96
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All: |
3 reference(s)
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Analysis Tools
