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| Nomenclature |
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Symbol:
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Ikbketm1Tman
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Name:
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inhibitor of kappaB kinase epsilon;
targeted mutation 1, Tom Maniatis
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MGI ID: |
MGI:3707541 |
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Synonyms: |
Ikbke- |
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Gene:
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Ikbke
Location:
Chr1:131254343-131279606 bp, - strand
Genetic Position: Chr1,
56.93 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:119791
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129 and C57BL/6
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 4-6 of the targeted gene were replaced with a PGK-neo cassette. Mice show a complete loss of the endogenous kinase function in lung, spleen, and embryonic fibroblasts. (J:119791)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:119791
Tenoever BR et al.,
"Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity."
Science 2007 Mar 2;315(5816):1274-8
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All: |
5 reference(s)
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Analysis Tools
