|
|
| Nomenclature |
|
Symbol:
|
Tg(UBC-cre/ERT2)1Ejb
|
|
Name:
|
transgene insertion 1, Eric J Brown
|
|
MGI ID: |
MGI:3707333 |
|
Synonyms: |
Cre-ER, Cre-ERT2, CreT2, Tg(UBC-cre)1Ejb, Tg(UBC-cre/ESR1)1Ejb, Ubc-cre, Ubc-creER, Ubc-cre/ERT2, UBC-CreERt2 |
|
Transgene:
|
Tg(UBC-cre/ERT2)1Ejb
Location:
unknown
|
|
Transgene
origin |
|
Strain of Origin:
|
(129S/SvEv x C57BL/6)
|
|
Transgene
description |
|
Transgene
Type: | |
Transgenic (Cre/Flp) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: This Cre-ERT2 transgenic mouse line was generated via lentitransgenesis; a self-inactivating lentiviral vector was designed with the human ubiquitin C (UBC) promoter sequence upstream of a Cre-ERT2 fusion gene (Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain). Cre-ERT2-expressing lentivirus were microinjected into the perivitelline space of one-cell zygotes (129SvEv;C57BL/6 mixed genetic background). Mice display tamoxifen-inducible Cre activity in all tissue types. (J:123200)
|
|
|
Recombinase activity
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
| References |
|
Original: |
J:123200
Ruzankina Y et al.,
"Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss."
Cell Stem Cell 2007 Jun 7;1(1):113-26
|
|
All: |
53 reference(s)
|
|
Analysis Tools
