|
|
| Nomenclature |
|
Symbol:
|
Cadps2tm1Tfr
|
|
Name:
|
Ca2+-dependent activator protein for secretion 2;
targeted mutation 1, Teiichi Furuichi
|
|
MGI ID: |
MGI:3707315 |
|
Synonyms: |
Caps2- |
|
Gene:
|
Cadps2
Location:
Chr6:23262773-23839420 bp, - strand
Genetic Position: Chr6,
10.57 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:121256
|
|
Parent Cell Line:
| MS12 (ES Cell) |
|
Strain of Origin:
|
C57BL/6CrSlc
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutations: | |
Insertion, Intragenic deletion |
| |
|
Mutation details: Exon 1 was replaced by a pgk-neo cassette flanked by loxP sites. Western blot confirmed absence of protein in mutant cerebellum, neocortex and hippocampus. (J:120106, J:121256)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Cadps2 Mutation:
|
1 strain or line available |
|
| References |
|
Original: |
J:121256
Sadakata T et al.,
"Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients."
J Clin Invest 2007 Apr;117(4):931-43
|
|
All: |
7 reference(s)
|
|
Analysis Tools
