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| Nomenclature |
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Symbol:
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Mapk14tm1.1Dvb
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Name:
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mitogen-activated protein kinase 14;
targeted mutation 1.1, Dmitry V Bulavin
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MGI ID: |
MGI:3706998 |
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Synonyms: |
p38AF, p38alphaki |
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Gene:
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Mapk14
Location:
Chr17:28691342-28748404 bp, + strand
Genetic Position: Chr17,
14.85 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:120284
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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C57BL/6
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Nucleotide substitutions |
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Mutation details: Regulatory sites Thr180 and Tyr182 are replaced by alanine and phenylalanine, respectively. A floxed neo cassette inserted downstream of exon 8 was removed by germ line, cre mediated recombination. (J:120284, J:151980)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:120284
Shreeram S et al.,
"Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase."
J Exp Med 2006 Dec 25;203(13):2793-9
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All: |
2 reference(s)
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Analysis Tools
