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| Nomenclature |
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Symbol:
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Rab27btm1.2Seab
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Name:
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RAB27b, member RAS oncogene family;
targeted mutation 1.2, Miguel C Seabra
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MGI ID: |
MGI:3706986 |
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Synonyms: |
Rab27b-, Rab27bnull |
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Gene:
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Rab27b
Location:
Chr18:69979131-70141605 bp, - strand
Genetic Position: Chr18,
43.89 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:120307
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Parent Cell Line:
| GSI-1 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Intragenic deletion |
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Mutation details: Cre mediated excision resulted in the loss of exons 2 and 3 and a neomycin resistance cassette. Western blot confirmed absence of protein in mutant mice. (J:120307)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Rab27b Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:120307
Tolmachova T et al.,
"Rab27b regulates number and secretion of platelet dense granules."
Proc Natl Acad Sci U S A 2007 Apr 3;104(14):5872-7
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All: |
3 reference(s)
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Analysis Tools
