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| Nomenclature |
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Symbol:
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Rbl2tm2Tyj
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Name:
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retinoblastoma-like 2;
targeted mutation 2, Tyler Jacks
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MGI ID: |
MGI:3706581 |
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Synonyms: |
p1302lox, p130conditional |
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Gene:
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Rbl2
Location:
Chr8:91070057-91123844 bp, + strand
Genetic Position: Chr8,
44.25 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:119919
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A targeting vector was used to introduce lox2722 sites on either side of exon 2, and place a hygromycin resistance cassette with a 3' loxP site in intron 2. Hygromycin was excised in vitro using Cre plasmid. (J:119919)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:119919
MacPherson D et al.,
"Murine bilateral retinoblastoma exhibiting rapid-onset, metastatic progression and N-myc gene amplification."
EMBO J 2007 Feb 7;26(3):784-94
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All: |
5 reference(s)
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Analysis Tools
