|
|
| Nomenclature |
|
Symbol:
|
Tg(Ins2-Nos2)40Okam
|
|
Name:
|
transgene insertion 40, Hiroshi Okamoto
|
|
MGI ID: |
MGI:3706439 |
|
Synonyms: |
line 40 |
|
Transgene:
|
Tg(Ins2-Nos2)40Okam
Location:
unknown
|
|
Transgene
origin |
|
Strain of Origin:
|
(C57BL/6 x DBA/2)F1
|
|
Transgene
description |
|
Transgene
Type: | |
Transgenic (random, expressed) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: The transgenic construct was composed of the rat insulin II promoter and the 3.5 kb cDNA fragment containing the entire mouse Nos2 gene coding region with the SV40 intron/polyadenylation signal ligated to it. Line 31 was subsequently established. Western blot analysis shows expression of Nos2 in pancreatic islets, but nowhere else. (J:45520)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
|
Notes |
J:116040 uses transgenic Nos2 mice with no identification of the line. The two lines created in J:45520 are similar, with line 40 having a more severe phenotype. Assumption was made that line 40 was used subsequently for this reason. rpb 05/01/1968
|
| References |
|
Original: |
J:45520
Takamura T et al.,
"Transgenic mice overexpressing type 2 nitric-oxide synthase in pancreatic beta cells develop insulin-dependent diabetes without insulitis."
J Biol Chem 1998 Jan 30;273(5):2493-6
|
|
All: |
4 reference(s)
|
|
Analysis Tools
