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| Nomenclature |
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Symbol:
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Abca3tm1Frm
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Name:
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ATP-binding cassette, sub-family A (ABC1), member 3;
targeted mutation 1, Mason W Freeman
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MGI ID: |
MGI:3706347 |
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Gene:
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Abca3
Location:
Chr17:24351950-24410201 bp, + strand
Genetic Position: Chr17,
12.38 cM, cytoband A3.3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:120296
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129/SvEv
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 4 and 5 are replaced with a zeo/neo cassette. The null allele was confirmed by the absence of protein in a western blot of homozygous embryonic tissue. (J:120296)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Abca3 Mutation:
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5 strains or lines available |
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| References |
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Original: |
J:120296
Fitzgerald ML et al.,
"ABCA3 inactivation in mice causes respiratory failure, loss of pulmonary surfactant, and depletion of lung phosphatidylglycerol."
J Lipid Res 2007 Mar;48(3):621-32
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All: |
1 reference(s)
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Analysis Tools
