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| Nomenclature |
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Symbol:
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Tg(tetO-BMPR2*T504)1Jwst
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Name:
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transgene insertion 1, James West
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MGI ID: |
MGI:3703793 |
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Synonyms: |
tetO7-BMPRIIdelx+, TetO7-BMPRIIdelx4+ |
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Transgene:
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Tg(tetO-BMPR2*T504)1Jwst
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: Seven copies of the tetracycline responsive element and the CMV minimal promotor were used to drive expression of a dominant-negative mutant BMPR2. The BMPR2 mutation is insertion of a T at base 504 in the kinase (4th) domain of the protein, resulting in a premature stop 18 amino acids into the kinase domain. These transgenic mice were crossed to Tg(Tagln-rtTA)E1Jwst mice to obtain mice with inducible, muscle-specific expression of dominant negative BMPR2. (J:98898)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:98898
West J et al.,
"Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle."
Circ Res 2004 Apr 30;94(8):1109-14
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All: |
6 reference(s)
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Analysis Tools
