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| Nomenclature |
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Symbol:
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Nebtm1Slbt
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Name:
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nebulin;
targeted mutation 1, Siegfried Labeit
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MGI ID: |
MGI:3703320 |
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Synonyms: |
NEB KO |
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Gene:
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Neb
Location:
Chr2:52136662-52338798 bp, - strand
Genetic Position: Chr2,
29.98 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:119578
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Parent Cell Line:
| IB10/E14IB10 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The cap site, TATA-box and its putative Tmod-binding aminoterminal domain in the 5' UTR were replaced with a neomycin resistance cassette. Western blot revealed absence of transcript in mutant mice. (J:119578)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Neb Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:119578
Witt CC et al.,
"Nebulin regulates thin filament length, contractility, and Z-disk structure in vivo."
EMBO J 2006 Aug 23;25(16):3843-55
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All: |
5 reference(s)
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Analysis Tools
