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| Nomenclature |
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Symbol:
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Slc6a3tm1(cre)Lrsn
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Name:
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solute carrier family 6 (neurotransmitter transporter, dopamine), member 3;
targeted mutation 1, Nils-Goran Larsson
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MGI ID: |
MGI:3702746 |
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Synonyms: |
DAT-cre |
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Gene:
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Slc6a3
Location:
Chr13:73536747-73578672 bp, + strand
Genetic Position: Chr13,
40.1 cM
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Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:119515
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: Cre recombinase cDNA and an frt-flanked neo cassette was inserted into exon 2. Crossing with mice expressiong FLP recombinase in the germline removed the neo. These mice express cre recombinase in nigrostriatal dopamine neurons of the midbrain. (J:119515)
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Recombinase activity
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Driver:
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Slc6a3
Summary of all recombinase alleles
driven by Slc6a3.
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MGI has not yet included tissue activity data for this allele in any anatomical systems.
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Slc6a3 Mutation:
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32 strains or lines available |
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| References |
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Original: |
J:119515
Ekstrand MI et al.,
"Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons."
Proc Natl Acad Sci U S A 2007 Jan 23;104(4):1325-30
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All: |
12 reference(s)
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Analysis Tools
