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| Nomenclature |
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Symbol:
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Wwtr1tm1Whun
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Name:
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WW domain containing transcription regulator 1;
targeted mutation 1, Walter Hunziker
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MGI ID: |
MGI:3702742 |
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Synonyms: |
Wwtr1- |
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Gene:
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Wwtr1
Location:
Chr3:57455649-57575910 bp, - strand
Genetic Position: Chr3,
27.74 cM
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Gross anatomy of skeleton and renal histology of Wwtr1tm1Whun/Wwtr1tm1Whun mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:119488
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Parent Cell Line:
| W4 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutation: | |
Insertion |
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Mutation details: A targeting vector was designed to insert a lacZ-neo cassette in frame into the second exon immediately downstream of the initiation ATG. Western blot failed to detect protein in mutant kidney samples, and lacZ expression was detected by X-gal staining. (J:119488)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Wwtr1 Mutation:
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7 strains or lines available |
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Notes |
Phenotypic Similarity to Human Syndrome: Nephronophthisis (J:119488)
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| References |
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Original: |
J:119488
Hossain Z et al.,
"Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1."
Proc Natl Acad Sci U S A 2007 Jan 30;104(5):1631-6
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All: |
1 reference(s)
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Analysis Tools
