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| Nomenclature |
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Symbol:
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Pdx1tm4Cvw
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Name:
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pancreatic and duodenal homeobox 1;
targeted mutation 4, Christopher V Wright
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MGI ID: |
MGI:3702084 |
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Synonyms: |
Ipf1tm3Cvw, Pdx1flE2, Pdx1tm4(E2)Cvw |
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Gene:
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Pdx1
Location:
Chr5:147269959-147278008 bp, + strand
Genetic Position: Chr5,
86.84 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:130389
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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LoxP sites for Cre recombinase were inserted to flank exon 2 of the gene. (J:130389)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:130389
Gannon M et al.,
"pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis."
Dev Biol 2008 Feb 15;314(2):406-17
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All: |
5 reference(s)
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Analysis Tools
