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| Nomenclature |
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Symbol:
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Tg(Cd4-CD4)2362Litt
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Name:
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transgene insertion 2362, Dan R Littman
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MGI ID: |
MGI:3702083 |
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Transgene:
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Tg(Cd4-CD4)2362Litt
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x SJL)F2
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A 4.5 kb BglII-EcoRI fragment encompassing a T cell-specific enhancer element located 13 kb upstream of the transcription initiation site in the murine CD4 gene was ligated to a 30 kb human CD4 minigene that includes the promoter and all of the human protein coding region. Line 2362 carries approximately six copies of this transgenic construct and expresses a level of CD4 equivalent to that seen on human peripheral CD4+ T cells. Transgenic mice do not express human CD4 on their peripheral CD8+ T cells, consistent with appropriate cis-acting transcriptional silencing of the human CD4 transgene from the T cell-specific enhancer element. (J:50435)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:50435
Killeen N et al.,
"Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4."
EMBO J 1993 Apr;12(4):1547-53
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All: |
3 reference(s)
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Analysis Tools
