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| Nomenclature |
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Symbol:
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Gt(ROSA)26Sortm1(cre/ERT2)Thl
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Name:
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gene trap ROSA 26, Philippe Soriano;
targeted mutation 1, Thomas Ludwig
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MGI ID: |
MGI:3701992 |
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Synonyms: |
ERCre, Gt(ROSA)26Sor-CreER, Gt(ROSA)26Sortm1(cre/ESR1)Thl, ROSA26Cre-ERT2 |
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Gene:
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Gt(ROSA)26Sor
Location:
Chr6:113067428-113077333 bp, - strand
Genetic Position: Chr6,
52.73 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:104582
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: DNA sequence encoding a fusion protein comprised of cre recombinase and a mutated ligand binding domain of Esr1 (ERT2) was inserted at the endogenous locus via homologous recombination. Activation of cre recombinase activity is dependent on the administration of 4-OH-tamoxifen. (J:104582)
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Recombinase activity
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Driver:
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Gt(ROSA)26Sor
Summary of all recombinase alleles
driven by Gt(ROSA)26Sor.
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MGI has not yet included tissue activity data for this allele in any anatomical systems.
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Gt(ROSA)26Sor Mutation:
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196 strains or lines available |
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| References |
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Original: |
J:104582
de Luca C et al.,
"Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes."
J Clin Invest 2005 Dec;115(12):3484-93
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All: |
38 reference(s)
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Analysis Tools
