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| Nomenclature |
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Symbol:
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Gcktm3Mgn
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Name:
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glucokinase;
targeted mutation 3, Mark A Magnuson
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MGI ID: |
MGI:3701764 |
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Synonyms: |
GK(A456V) |
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Gene:
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Gck
Location:
Chr11:5900820-5950081 bp, - strand
Genetic Position: Chr11,
3.88 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:121910
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Parent Cell Line:
| TL1/TL-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Nucleotide substitutions |
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Mutation details: ES cells were modified using a construct with an activating single base mutation introduced into exon 10 via site specific mutagenesis to change amino acid 456 from alanine to valine. (J:121910)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
On congenic B6 background, analysis is done on mice with allele with pgk-neo selection cassette deleted through mating to cre transgenic mice; on the coisogenic 129S6 background, allele retaining pgk-neo is analyzed, and authors state that presence of neo has no apparent effect on phenotype compared with mice on C57BL/6J congenic background. MMRRC has B6 congenic mice carrying Gcktm3Mgn allele (with neo deleted.)
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| References |
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Original: |
J:121910
Pino MF et al.,
"Glucokinase thermolability and hepatic regulatory protein binding are essential factors for predicting the blood glucose phenotype of missense mutations."
J Biol Chem 2007 May 4;282(18):13906-16
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All: |
1 reference(s)
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Analysis Tools
