|
|
| Nomenclature |
|
Symbol:
|
Sall4tm1Ryn
|
|
Name:
|
sal-like 4 (Drosophila);
targeted mutation 1, Ryuichi Nishinakamura
|
|
MGI ID: |
MGI:3699175 |
|
Synonyms: |
Sall4-del |
|
Gene:
|
Sall4
Location:
Chr2:168748332-168767943 bp, - strand
Genetic Position: Chr2,
88.99 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:118119
|
|
Parent Cell Line:
| E14.1 (ES Cell) |
|
Strain of Origin:
|
129P2/OlaHsd
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutations: | |
Insertion, Intragenic deletion |
| |
|
Mutation details: The entire coding region was deleted and replaced with beta-galactosidase and neomycin resistance genes. The mutation removes all eight zinc finger domains from the gene and results in the fusion of 39 amino acids at the N terminal of Sall4 and beta-galactosidase. Although a beta-galactosidase gene was inserted, lacZ is not expressed. (J:118119)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
| References |
|
Original: |
J:118119
Sakaki-Yumoto M et al.,
"The murine homolog of SALL4, a causative gene in Okihiro syndrome, is essential for embryonic stem cell proliferation, and cooperates with Sall1 in anorectal, heart, brain and kidney development."
Development 2006 Aug;133(15):3005-13
|
|
All: |
1 reference(s)
|
|
Analysis Tools
