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| Nomenclature |
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Symbol:
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Park2tm1Ykt
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Name:
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Parkinson disease (autosomal recessive, juvenile) 2, parkin;
targeted mutation 1, Yasuko Kitao
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MGI ID: |
MGI:3698054 |
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Gene:
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Park2
Location:
Chr17:10840384-12063361 bp, + strand
Genetic Position: Chr17,
7.8 cM, cytoband A3.2-A3.3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:117737
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 3 was replaced with a floxed pgk-neomycin cassette. Absence of protein was confirmed by Western blot analysis. (J:117737)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Park2 Mutation:
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13 strains or lines available |
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| References |
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Original: |
J:117737
Kitao Y et al.,
"Pael receptor induces death of dopaminergic neurons in the substantia nigra via endoplasmic reticulum stress and dopamine toxicity, which is enhanced under condition of parkin inactivation."
Hum Mol Genet 2007 Jan 1;16(1):50-60
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All: |
5 reference(s)
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Analysis Tools
