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| Nomenclature |
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Symbol:
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Apba2tm1Tsuz
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Name:
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amyloid beta (A4) precursor protein-binding, family A, member 2;
targeted mutation 1, Toshiharu Suzuki
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MGI ID: |
MGI:3697454 |
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Synonyms: |
X11L-KO |
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Gene:
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Apba2
Location:
Chr7:64501706-64753870 bp, + strand
Genetic Position: Chr7,
34.65 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:117646
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Parent Cell Line:
| MS12 (ES Cell) |
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Strain of Origin:
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C57BL/6CrSlc
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A PGK-neo cassette replaced sequence containing the ATG by homologous recombination and was subsequently removed via cremediated recombination. Western blot failed to detect protein in mutant mice. (J:117646)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Apba2 Mutation:
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1 strain or line available |
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| References |
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Original: |
J:117646
Sano Y et al.,
"Enhanced amyloidogenic metabolism of the amyloid beta-protein precursor in the X11L-deficient mouse brain."
J Biol Chem 2006 Dec 8;281(49):37853-60
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All: |
4 reference(s)
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Analysis Tools
