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| Nomenclature |
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Symbol:
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Glra1tm1Betz
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Name:
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glycine receptor, alpha 1 subunit;
targeted mutation 1, Heinrich Betz
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MGI ID: |
MGI:3696673 |
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Synonyms: |
Glra1(D80A) |
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Gene:
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Glra1
Location:
Chr11:55514238-55608198 bp, - strand
Genetic Position: Chr11,
33.12 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:117236
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Nucleotide substitutions |
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The D80A substitution was inserted into exon 4. (J:117236)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Glra1 Mutation:
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5 strains or lines available |
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| References |
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Original: |
J:117236
Hirzel K et al.,
"Hyperekplexia phenotype of glycine receptor alpha1 subunit mutant mice identifies Zn(2+) as an essential endogenous modulator of glycinergic neurotransmission."
Neuron 2006 Nov 22;52(4):679-90
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All: |
1 reference(s)
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Analysis Tools
