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| Nomenclature |
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Symbol:
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Brca1tm1Brn
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Name:
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breast cancer 1;
targeted mutation 1, Anton Berns
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MGI ID: |
MGI:3696057 |
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Synonyms: |
Brca1F, Brca1F5-13, Brca1loxP, Brca1tm2Brn |
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Gene:
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Brca1
Location:
Chr11:101488764-101551955 bp, - strand
Genetic Position: Chr11,
65.18 cM, cytoband D
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:117113
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: LoxP sites were introduced into introns 3 and 13 to flox exons 5 through 13. A neo cassette, inserted as a selectable marker, was removed following a cross to a cre deletor strain (Tg(CMV-cre)1Cgn mice). Southern blot analysis was used to confirm genomic modifications. (J:126551)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:117113
Clark-Knowles KV et al.,
"Conditional inactivation of Brca1 in the mouse ovarian surface epithelium results in an increase in preneoplastic changes."
Exp Cell Res 2007 Jan 1;313(1):133-45
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All: |
13 reference(s)
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Analysis Tools
