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| Nomenclature |
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Symbol:
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Tg(SOD1*)125Dbo
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Name:
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transgene insertion 125, David Borschelt
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MGI ID: |
MGI:3695897 |
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Synonyms: |
H46R/H48Q/H63G/H120G, SOD1-Quad |
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Transgene:
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Tg(SOD1*)125Dbo
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C3H/HeJ x C57BL/6J)F2
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The H46R/H48Q/H63G/H120G mutation was engineered into
a 12 kb fragment of human genomic DNA, encompassing the
entire SOD1 gene. In addition to line 125, line 71 was also generated. (J:86421)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:86421
Wang J et al.,
"Copper-binding-site-null SOD1 causes ALS in transgenic mice: aggregates of non-native SOD1 delineate a common feature."
Hum Mol Genet 2003 Nov 1;12(21):2753-64
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All: |
2 reference(s)
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Analysis Tools
