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| Nomenclature |
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Symbol:
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Tg(SOD1*H46R*H48Q)58Dbo
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Name:
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transgene insertion 58, David Borschelt
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MGI ID: |
MGI:3695884 |
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Transgene:
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Tg(SOD1*H46R*H48Q)58Dbo
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C3H/HeJ x C57BL/6J)F2
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A 12kb genomic fragment containing the entire human SOD1 gene was mutated so that the histidine residue at position 46 was replaced by arginine and the histidine at position 48 was replaced by glutamine in the encoded protein. This line is the representative line of 10 that developed motor neuron disease before 1 year of age. Lines 73, 67, and 58 show identical pathological changes. (J:119631)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:119631
Wang J et al.,
"Fibrillar inclusions and motor neuron degeneration in transgenic mice expressing superoxide dismutase 1 with a disrupted copper-binding site."
Neurobiol Dis 2002 Jul;10(2):128-38
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All: |
8 reference(s)
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Analysis Tools
