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| Nomenclature |
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Symbol:
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Abcg1tm1Dgen
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Name:
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ATP-binding cassette, sub-family G (WHITE), member 1;
targeted mutation 1, Deltagen
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MGI ID: |
MGI:3695417 |
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Synonyms: |
Abcg1- |
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Gene:
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Abcg1
Location:
Chr17:31057698-31115777 bp, + strand
Genetic Position: Chr17,
15.8 cM, cytoband A2-B
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:117028
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A targeting vector was used to replace 21 bp, encoding seven amino acids (GPSGAGK), in exon 3 with a floxed IRES-lacZ-neo-pA cassette. (J:117028)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Abcg1 Mutation:
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15 strains or lines available |
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Notes |
When used in bone marrow transplant into Ldlrtm1Her homozygous mice, Abca1tm1Jdm Abcg1tm1Dgen homozygous cells accelerate the development of atherosclerosis. (J:130777)
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| References |
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Original: |
J:117028
Kennedy MA et al.,
"ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation."
Cell Metab 2005 Feb;1(2):121-31
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All: |
39 reference(s)
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Analysis Tools
