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| Nomenclature |
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Symbol:
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Tg(APPSwLon)96Btla
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Name:
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transgene insertion 96, Bruce Lamb
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MGI ID: |
MGI:3693359 |
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Synonyms: |
APPK670N/M671L and APPV717Im, J1.96, K670N/M671L + V717I |
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Transgene:
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Tg(APPSwLon)96Btla
Location:
unknown
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Transgene
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:42613
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A 650 kb YAC transgene containing the entire human amyloid beta (A4) precursor protein gene and approximately 250 kb of flanking sequence was altered to include the Familial Alzheimer's Disease- (FAD-) associated "Swedish" double mutation, APPK670N/M671L, and the "London" mutation, APPV717I. RT-PCR analysis shows hemizygous mice express the mutant human and endogenous mouse APP mRNA at similar levels in brain and peripheral tissues; levels of the most common alternative splice variants (encoding human APP-695, -751 and -770) parallel those of the endogenous mouse transcripts. Levels of total amyloid-beta and of longer amyloid-beta peptides (species terminating at amino acids 42/43) are higher than in wildtype mice, but not as high as in a similar strain carrying only the APPK670N/M671L "Swedish" mutant transgene. (J:42613)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
The transgene construct was injected into embryonic stem (ES) cells.
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| References |
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Original: |
J:42613
Lamb BT et al.,
"Altered metabolism of familial Alzheimer's disease-linked amyloid precursor protein variants in yeast artificial chromosome transgenic mice."
Hum Mol Genet 1997 Sep;6(9):1535-41
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All: |
2 reference(s)
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Analysis Tools
