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| Nomenclature |
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Symbol:
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Irf6tm1Mjd
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Name:
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interferon regulatory factor 6;
targeted mutation 1, Michael J Dixon
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MGI ID: |
MGI:3693324 |
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Synonyms: |
Irf6R84C |
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Gene:
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Irf6
Location:
Chr1:193153112-193172042 bp, + strand
Genetic Position: Chr1,
97.6 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:116077
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Nucleotide substitutions |
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Mutation details: A vector was designed to insert the R84C mutation into exon 3. A neo included in the vector was removed via transient cre expression. (J:116077)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Irf6 Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:116077
Richardson RJ et al.,
"Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch."
Nat Genet 2006 Nov;38(11):1329-34
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All: |
6 reference(s)
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Analysis Tools
