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| Nomenclature |
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Symbol:
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Tg(ACTA1-PABPN1*A17)1Drub
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Name:
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transgene insertion 1, David Rubinsztein
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MGI ID: |
MGI:3693304 |
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Synonyms: |
A17-1, A17.1 |
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Transgene:
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Tg(ACTA1-PABPN1*A17)1Drub
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene contains the human skeletal actin promoter upstream of a mutant bovine cDNA with a series of CGC codons encoding a 17-amino acid polyalanine tract. (J:115642)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Of two lines descended from founders with this transgenic construct, line A7-1 has a more severe phenotype, correlated with higher transgene expression levels, than line A7-2.
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| References |
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Original: |
J:115642
Davies JE et al.,
"Doxycycline attenuates and delays toxicity of the oculopharyngeal muscular dystrophy mutation in transgenic mice."
Nat Med 2005 Jun;11(6):672-7
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All: |
6 reference(s)
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Analysis Tools
