Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas
Transgene Detail
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| Nomenclature |
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Symbol:
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Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas
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Name:
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transgene insertion 6799, Robert Vassar
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MGI ID: |
MGI:3693208 |
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Synonyms: |
5XFAD, 5XFAD APP/PS1, 5XFAD line Tg6799, Tg6799 |
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Transgene:
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Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x SJL)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: Four familial Alzheimer disease- (FAD-) associated mutations were introduced into a single human amyloid precursor protein cDNA: the "Swedish" double mutation (K670N/M671L); the "Florida" mutation (I716V); and the "London" mutation (V717I). Two FAD-associated mutations, M146L and L286V, likewise were introduced into a human presenilin 1 cDNA. Each cDNA was then cloned independently into the mouse thymus cell antigen 1 gene, replacing a segment that contains thymus-specific elements so that expression of the transgenes is targeted only to the brain. Equal molar amounts of the two transgenes were coinjected into pronuclei of single-celled embryos. (J:32213, J:112949)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Three transgenic lines coexpressing the APP and PSEN1 proteins at high, medium and low levels, respectively designated Tg6799, Tg7031, and Tg7092, were propagated for analysis, most of which employed Tg6799.
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| References |
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Original: |
J:112949
Oakley H et al.,
"Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation."
J Neurosci 2006 Oct 4;26(40):10129-40
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All: |
30 reference(s)
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Analysis Tools
