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| Nomenclature |
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Symbol:
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Ercc1tm2Dwm
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Name:
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excision repair cross-complementing rodent repair deficiency, complementation group 1;
targeted mutation 2, David W Melton
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MGI ID: |
MGI:3692923 |
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Synonyms: |
Ercc1flox |
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Gene:
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Ercc1
Location:
Chr7:19344778-19356524 bp, + strand
Genetic Position: Chr7,
9.6 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:115849
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Parent Cell Line:
| HM-1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd-Hprtb-m3
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: In the first step of a two step process, exons 3-5 were replaced with an Hprt minigene. In the second step, the Hprt1 marker was replaced with the Ercc1 exons 3-5 region flanked by loxP sites. (J:115849)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ercc1 Mutation:
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6 strains or lines available |
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| References |
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Original: |
J:115849
Doig J et al.,
"Mice with skin-specific DNA repair gene (Ercc1) inactivation are hypersensitive to ultraviolet irradiation-induced skin cancer and show more rapid actinic progression."
Oncogene 2006 Oct 12;25(47):6229-38
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All: |
4 reference(s)
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Analysis Tools
