|
|
| Nomenclature |
|
Symbol:
|
Tg(Myh6-Tnnt2)191Lnwd
|
|
Name:
|
transgene insertion 191, Leslie A Leinwand
|
|
MGI ID: |
MGI:3692603 |
|
Transgene:
|
Tg(Myh6-Tnnt2)191Lnwd
Location:
unknown
|
|
Transgene
origin |
|
Strain of Origin:
|
Not Specified
|
|
Transgene
description |
|
Transgene
Type: | |
Transgenic (random, expressed) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: This transgene expresses a carboxy-terminal truncated mouse Tnnt2 gene under the control of a rat alpha-myosin heavy chain promoter. The truncation corresponds to a truncation described in familial hypertrophic cardiomyopathy patients in which exons 15 and 16 are missing. This line expresses less than 5% of total Tnnt2 as the mutant transgenic form but expresses slightly more transgene than line 117. (J:48301)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
| References |
|
Original: |
J:48301
Tardiff JC et al.,
"A truncated cardiac troponin T molecule in transgenic mice suggests multiple cellular mechanisms for familial hypertrophic cardiomyopathy."
J Clin Invest 1998 Jun 15;101(12):2800-11
|
|
All: |
7 reference(s)
|
|
Analysis Tools
