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| Nomenclature |
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Symbol:
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Acadmtm1Uab
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Name:
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acyl-Coenzyme A dehydrogenase, medium chain;
targeted mutation 1, University of Alabama
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MGI ID: |
MGI:3692446 |
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Synonyms: |
MCAD- |
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Gene:
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Acadm
Location:
Chr3:153922357-153944632 bp, - strand
Genetic Position: Chr3,
78.77 cM
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Histopathology of wild-type and Acadmtm1Uab/Acadmtm1Uab mice.
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:115759
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Parent Cell Line:
| E14.1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A targeting vector was designed duplicate exons 8-10. Translation of the duplicated exon 8 resullted in the formation of a premature stop codon and therefore the resulting protein lacks the C-terminal domain alpha-helixes. (J:115759)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:115759
Tolwani RJ et al.,
"Medium-chain acyl-CoA dehydrogenase deficiency in gene-targeted mice."
PLoS Genet 2005 Aug;1(2):e23
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All: |
2 reference(s)
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Analysis Tools
