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| Nomenclature |
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Symbol:
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Serpinc1tm1Dwr
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Name:
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serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1;
targeted mutation 1, Mieke Dewerchin
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MGI ID: |
MGI:3692385 |
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Synonyms: |
ATm |
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Gene:
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Serpinc1
Location:
Chr1:160978606-161003010 bp, + strand
Genetic Position: Chr1,
69.75 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:115658
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Nucleotide substitutions |
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Mutation details: Exon 2 was replaced with a mutant exon 2 encoding the R48C substitution and an additional silent mutation creating a SacI site. (J:115658)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Serpinc1 Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:115658
Dewerchin M et al.,
"Life-threatening thrombosis in mice with targeted Arg48-to-Cys mutation of the heparin-binding domain of antithrombin."
Circ Res 2003 Nov 28;93(11):1120-6
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All: |
1 reference(s)
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Analysis Tools
