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| Nomenclature |
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Symbol:
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Slc25a19tm1Mjl
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Name:
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solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19;
targeted mutation 1, Marjorie J Lindhurst
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MGI ID: |
MGI:3691853 |
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Synonyms: |
Slc25a19- |
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Gene:
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Slc25a19
Location:
Chr11:115614178-115628281 bp, - strand
Genetic Position: Chr11,
80.91 cM, cytoband E2
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Examples of Slc25a19tm1Mjl/+ control and Slc25a19tm1Mjl/Slc25a19tm1Mjl embryos at E10.5
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:115337
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Parent Cell Line:
| TC1/TC-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Disruption caused by insertion of vector |
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Mutation details: Exons 4-6 were replaced with a neomycin resistance cassette, causing the deletion of amino acids 97-258 and rendering the protein nonfunctional. (J:115337)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Slc25a19 Mutation:
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23 strains or lines available |
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| References |
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Original: |
J:115337
Lindhurst MJ et al.,
"Knockout of Slc25a19 causes mitochondrial thiamine pyrophosphate depletion, embryonic lethality, CNS malformations, and anemia."
Proc Natl Acad Sci U S A 2006 Oct 24;103(43):15927-32
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All: |
1 reference(s)
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Analysis Tools
