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| Nomenclature |
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Symbol:
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Slc6a3tm1(cre)Xz
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Name:
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solute carrier family 6 (neurotransmitter transporter, dopamine), member 3;
targeted mutation 1, Xiaoxi Zhuang
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MGI ID: |
MGI:3691571 |
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Synonyms: |
DAT-cre, Slc6a3Cre |
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Gene:
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Slc6a3
Location:
Chr13:73536747-73578672 bp, + strand
Genetic Position: Chr13,
40.1 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:115426
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Parent Cell Line:
| W9.5/W95 (ES Cell) |
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Strain of Origin:
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129S1/Sv-Oca2+ Tyr+ Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: A targeting vector was constructed by inserting a cassette with the cre recombinase coding sequence, a nuclear translocation signal, and a PGK-neo gene flanked by FRT sites, into the 5'-UTR of the Slc6a3 gene. After homologous recombination in ES cells, mice with cre recombinase expressed from the Slc6a3 gene were produced. Knockin mice were crossed with transgenic Flp deleter mice to remove the neo marker. A line was established where the neo was removed and the Flp transgene was absent. Cre recombinase expression is detected in the ventral tegmental area (VAT) and substantia nigra zona compacta (SNc). (J:115426)
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Recombinase activity
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:115426
Zhuang X et al.,
"Targeted gene expression in dopamine and serotonin neurons of the mouse brain."
J Neurosci Methods 2005 Apr 15;143(1):27-32
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All: |
28 reference(s)
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Analysis Tools
