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| Nomenclature |
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Symbol:
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Pik3catm1Jjz
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Name:
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phosphatidylinositol 3-kinase, catalytic, alpha polypeptide;
targeted mutation 1, Jean J Zhao
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MGI ID: |
MGI:3691486 |
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Synonyms: |
p110alphaflox, p110alpha flox |
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Gene:
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Pik3ca
Location:
Chr3:32397671-32466107 bp, + strand
Genetic Position: Chr3,
15.7 cM, cytoband B
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:115274
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: Exon 1 was flanked by lox P sites, with an FRT-flanked selection cassette between exon 1 and the downstream loxP site. The selection cassette was subsequently removed from the locus via transient transfection with a FLP recombinase plasmid. (J:115274)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:115274
Zhao JJ et al.,
"The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation."
Proc Natl Acad Sci U S A 2006 Oct 31;103(44):16296-300
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All: |
6 reference(s)
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Analysis Tools
