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| Nomenclature |
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Symbol:
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Kmt2atm1Clgr
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Name:
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lysine (K)-specific methyltransferase 2A;
targeted mutation 1, Michael A Caligiuri
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MGI ID: |
MGI:3691062 |
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Synonyms: |
MllPTD |
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Gene:
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Kmt2a
Location:
Chr9:44803355-44881296 bp, - strand
Genetic Position: Chr9,
24.84 cM
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Vertebral transformation is seen in Kmt2atm1Clgr/Mll1+ mice at 20 weeks of age
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:115001
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: Exons 5-11 were targeted to intron 4 of the locus. RT-PCR and sequencing detected a correctly spliced, in-frame fusion transcript confirming the correct targeting of the vector. (J:115001)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Kmt2a Mutation:
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12 strains or lines available |
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| References |
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Original: |
J:115001
Dorrance AM et al.,
"Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations."
J Clin Invest 2006 Oct;116(10):2707-16
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All: |
4 reference(s)
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Analysis Tools
